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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HIRA
All Species:
21.21
Human Site:
S549
Identified Species:
29.17
UniProt:
P54198
Number Species:
16
Phosphosite Substitution
Charge Score:
0.06
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P54198
NP_003316.3
1017
111835
S549
T
S
T
P
A
A
L
S
P
S
V
L
T
T
P
Chimpanzee
Pan troglodytes
XP_001165585
1017
111787
S549
T
S
T
P
A
A
L
S
P
S
V
L
T
T
P
Rhesus Macaque
Macaca mulatta
XP_001112873
1138
124408
S670
T
S
T
P
A
A
L
S
P
S
V
L
T
T
P
Dog
Lupus familis
XP_543550
1017
111618
S549
T
S
T
P
A
A
S
S
P
S
V
L
T
T
P
Cat
Felis silvestris
Mouse
Mus musculus
Q61666
1015
111748
P549
S
T
P
A
A
S
S
P
S
V
L
T
T
P
S
Rat
Rattus norvegicus
NP_001129232
1015
111665
P549
S
T
P
A
A
L
S
P
S
V
L
T
T
P
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
P79987
1019
112055
T549
V
N
A
T
S
V
S
T
A
P
P
A
S
S
S
Frog
Xenopus laevis
Q8QFR2
1013
112021
T549
S
S
S
P
V
A
P
T
S
I
T
A
Q
P
K
Zebra Danio
Brachydanio rerio
XP_696478
1010
111223
S549
K
S
T
L
L
L
T
S
A
S
K
I
E
P
M
Tiger Blowfish
Takifugu rubipres
O42611
1025
111838
T549
V
K
S
C
L
L
L
T
S
A
S
K
I
E
P
Fruit Fly
Dros. melanogaster
O17468
1047
113397
P546
H
Q
S
S
T
C
S
P
S
N
L
N
V
T
A
Honey Bee
Apis mellifera
XP_001122939
838
91355
S395
E
L
L
N
L
K
T
S
V
P
S
T
Q
T
T
Nematode Worm
Caenorhab. elegans
Q09589
935
103412
S492
D
P
M
T
S
L
S
S
E
G
K
K
T
V
A
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Q32SG6
964
105548
D521
P
V
N
F
S
S
L
D
Q
R
M
N
G
T
K
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9LXN4
1051
115544
R549
E
R
S
R
I
T
A
R
A
T
I
T
E
S
L
Baker's Yeast
Sacchar. cerevisiae
P32479
840
93871
E397
L
G
K
P
I
P
L
E
K
N
M
E
Q
L
Y
Red Bread Mold
Neurospora crassa
Q7RZI0
1035
112420
P547
S
K
P
Y
D
G
L
P
R
G
G
I
A
A
M
Conservation
Percent
Protein Identity:
100
99.9
88.4
96.5
N.A.
95.7
95.5
N.A.
N.A.
86
78
69.8
67.7
31.1
40
26.5
N.A.
Protein Similarity:
100
99.9
88.9
98
N.A.
97.5
97.7
N.A.
N.A.
93.1
88.5
83.2
81.3
48
55.1
46.1
N.A.
P-Site Identity:
100
100
100
93.3
N.A.
13.3
13.3
N.A.
N.A.
0
20
26.6
13.3
6.6
13.3
13.3
N.A.
P-Site Similarity:
100
100
100
93.3
N.A.
40
33.3
N.A.
N.A.
33.3
40
33.3
33.3
26.6
13.3
20
N.A.
Percent
Protein Identity:
N.A.
25.6
N.A.
25
22.4
25.9
Protein Similarity:
N.A.
43.7
N.A.
43.3
41.2
45.8
P-Site Identity:
N.A.
13.3
N.A.
0
13.3
6.6
P-Site Similarity:
N.A.
33.3
N.A.
26.6
26.6
20
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
6
12
36
30
6
0
18
6
0
12
6
6
12
% A
% Cys:
0
0
0
6
0
6
0
0
0
0
0
0
0
0
0
% C
% Asp:
6
0
0
0
6
0
0
6
0
0
0
0
0
0
0
% D
% Glu:
12
0
0
0
0
0
0
6
6
0
0
6
12
6
0
% E
% Phe:
0
0
0
6
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
6
0
0
0
6
0
0
0
12
6
0
6
0
0
% G
% His:
6
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
12
0
0
0
0
6
6
12
6
0
0
% I
% Lys:
6
12
6
0
0
6
0
0
6
0
12
12
0
0
12
% K
% Leu:
6
6
6
6
18
24
42
0
0
0
18
24
0
6
6
% L
% Met:
0
0
6
0
0
0
0
0
0
0
12
0
0
0
12
% M
% Asn:
0
6
6
6
0
0
0
0
0
12
0
12
0
0
0
% N
% Pro:
6
6
18
36
0
6
6
24
24
12
6
0
0
24
30
% P
% Gln:
0
6
0
0
0
0
0
0
6
0
0
0
18
0
0
% Q
% Arg:
0
6
0
6
0
0
0
6
6
6
0
0
0
0
0
% R
% Ser:
24
36
24
6
18
12
36
42
30
30
12
0
6
12
18
% S
% Thr:
24
12
30
12
6
6
12
18
0
6
6
24
42
42
6
% T
% Val:
12
6
0
0
6
6
0
0
6
12
24
0
6
6
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
6
0
0
0
0
0
0
0
0
0
0
6
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _